INTOXICACION POR PARACETAMOL PDF

Efficient diagnosis and treatment of acute paracetamol poisoning: posibles ante la sospecha de intoxicación aguda (IA) por paracetamol (PCT) a través de un. These are the options to access the full texts of the publication Nursing. Subscriber. Subscriber. If you already have your login data, please click here. Since its clinical introduction in ,(N-acetyl-p-aminophenol; APAP; paracetamol) has become the most widely used analgesic-antipyretic in.

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Itnoxicacion pharmacologic poisoning II. Izura 2G. Burillo-Putze 3S. Within the group of analgesic-anti-inflammatory drugs we consider paracetamol and the salicylates, which are easily available to the population.

Intoxicação por paracetamol

With respect to the anticonvulsants, although they are barely involved in the ensemble of acute drug poisonings, their effects can be serious. We concentrate on four drugs: Finally, a section is dedicated to isoniazid, a drug that, with the renewed incidence of tuberculosis, is of toxicological interest.

En casos de sobredosis puede alcanzar las 12 horas. Aunque muy inusual pueden haber AST elevadas al cabo de h en caso de sobredosis muy copiosas.

Debido a ello, es necesario prolongar el tratamiento con NAC i. Intoxicwcion se use la pauta intravenosa 21 horasdebe administrarse la totalidad del tratamiento. En caso de hipertermia severa, a su vez, puede ser causa de rabdomiolisis Pueden objetivarse hiperreflexia y convulsiones. Las de mayor utilidad son las siguientes: Control riguroso de la potasemia.

Intoxicaciones medicamentosas (II): Analgésicos y anticonvulsivantes

Puede administrarse vitamina K. En caso de sangrado activo, plasma fresco. A nivel digestivo, se han visto pancreatitis asociadas tanto a la ingesta prolongada como a episodios de sobredosis Episodios de hepatotoxicidad son menos frecuentes en situaciones agudas. A partir de los 30 minutos pueden detectarse niveles en sangre aunque el pico se alcanza a las 4 horas.

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El coma es proporcional a la dosis ingerida y se potencia por el alcohol Puede haber rabdomiolisis e insuficiencia renal aguda. La vida media del CBZE es de 8 a 14 horas En caso de convulsiones tratamiento con benzodiacepinas. Se distribuye por todos los tejidos y fluidos corporales Cruza la barrera placentaria.

Se cree que uno de los metabolitos de esta acetilhidracina es el responsable de la hepatotoxicidad inducida por INH. Si la ingesta ha sido hace menos de una hora, realizar lavado. National multicenter study of acute intoxication in Emergengy Departments of Spain. Eur J Emerg Med en prensa. Rev Esp Pediatr ; Effect of food on acetaminophen absorption in young and elderly subjects. J Clin Pharmacol ; Delayed peak acetaminophen APAP levels abstract.

J Toxicol Clin Toxicol ; Disposition of Toxic Drugs and Chemicals in Man. Chemical Toxicology Institute, Evidence that acetaminophen and N-hydroxiacetaminophen from a common arylating intermediate. Mol Pharmacol ; Evidence for redox cycling of acetaminophen and its reactive metabolite by endogenous microsomal systems.

Role of drug metabolism.

J Pharmacol Exp Ther ; Gender-related differences in susceptibility to acetaminophen-induced imtoxicacion arylation and nephrotoxicity on the CD-1 mouse.

Toxicol Appl Pharmacol ; Protection against acetaminophen-induced liver injury in vivo by an iron chelator, deferoxamine. Scand J Gastroenterol ; Jaeschke H, Mitchell JR.

Neutrophil accumulation exacerbates acetaminophen-induced liver injury. Subcellular brinding and effects on calcium homeostasis produced by acetaminophen and a non-hepatotoxic regioisomer, 3 hydroxyacetoanilide in mouse liver. J Biol Chem ; Inhibition of mitochondrial respiration in vivo is an early event in acetaminophen-induced hepatotoxicity.

King’s College Criteria for Acetaminophen Toxicity – MDCalc

Arch Toxicol ; Acetaminophen causes an increased international normalized ratio by reducing functional factor VII. Ther Drug Monitor ; Hyperglicemia induced by paracetamol. Postgrad Med J ; Pancytopenia, hyperglycemia, shock, coma, rhabdomyolisis, and pancreatitis associated with acetaminophen poisoning. Vet Human Toxicol ; Eguia L, Materson BJ. Acetaminophen-related acute renal failure without fulminant liver failure.

Paracetamol-induced acute renal failure in the absence of fulminant liver damage. Acetaminophen overdose in children and adolescents. Pediatr Clin North Am ; N Engl J Med ; Ethanol and production of the hepatotoxic metabolite of acetaminophen in healthy adults. Clin Pharmacol Ther ; Acetaminophen overdose in young children: Treatment and effects of alcohol and other additional ingestants in cases. Am J Dis Child ; Severe acetaminophen toxicity in a patient receiving isoniazid.

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Ann Intern Med ; Activated charcoal reduces the need for N-acetylcysteine treatment after acetaminophen paracetamol overdose. Comparison of activated charcoal and ipecac syrup in prevention of drug absorption. Eur J Clin Pharmacol ; A prospective evaluation of the effect of activated charcoal before oral N-acetylcisteine on indirect indicators of tissue oxygenation in septic shock patients. Crit Care Med ; Unintentional acetaminophen ingestion in children and the potential for hepatotoxicity.

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Mechanism of action of N-acetylcysteine in the protection against hepatotoxicity of acetaminophen in rats in vivo. J Clin Invest ; Varying effects sulfhydryl nucleophiles on acetaminophen oxidation and sulfhydryl adduct formation. Biochem Pharmacol ; Dose-dependent pharmacokinetics of acetaminophen: Evidence for glutathione depletion in humans. Rumack BH, Matthew H. Acetaminophen poisoning and toxicity. Lesson of the week, Deaths from low-dose paracetamol poisoning.

Br Med J ; Ann Emerg Med ; Intravenous acetylcysteine in paracetamol induced fulminant hepatic failure: A prospective controlled trial.

Interaction between N-acetylcysteine and activated charcoal: Use of activated charcoal. Elimination halflife as a predictor of acetaminophen-induced hepatotoxicity abstract.

Shorter duration of n-acetylcysteine NAC for acute acetaminophen intoxicaicon. Compliance with PCC recommendations: Blood lactate as an early predictor of outcome in paracetamol-induced acute liver failure: Pharmacological basis of therapeutics, 6th ed.

New York, MacMillan Co. Levy G, Leonards JR.