Efficient diagnosis and treatment of acute paracetamol poisoning: posibles ante la sospecha de intoxicación aguda (IA) por paracetamol (PCT) a través de un. These are the options to access the full texts of the publication Nursing. Subscriber. Subscriber. If you already have your login data, please click here. Since its clinical introduction in ,(N-acetyl-p-aminophenol; APAP; paracetamol) has become the most widely used analgesic-antipyretic in.

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Itnoxicacion pharmacologic poisoning II. Izura 2G. Burillo-Putze 3S. Within the group of analgesic-anti-inflammatory drugs we consider paracetamol and the salicylates, which are easily available to the population.

Intoxicação por paracetamol

With respect to the anticonvulsants, although they are barely involved in the ensemble of acute drug poisonings, their effects can be serious. We concentrate on four drugs: Finally, a section is dedicated to isoniazid, a drug that, with the renewed incidence of tuberculosis, is of toxicological interest.

En casos de sobredosis puede alcanzar las 12 horas. Aunque muy inusual pueden haber AST elevadas al cabo de h en caso de sobredosis muy copiosas.

Debido a ello, es necesario prolongar el tratamiento con NAC i. Intoxicwcion se use la pauta intravenosa 21 horasdebe administrarse la totalidad del tratamiento. En caso de hipertermia severa, a su vez, puede ser causa de rabdomiolisis Pueden objetivarse hiperreflexia y convulsiones. Las de mayor utilidad son las siguientes: Control riguroso de la potasemia.

Intoxicaciones medicamentosas (II): Analgésicos y anticonvulsivantes

Puede administrarse vitamina K. En caso de sangrado activo, plasma fresco. A nivel digestivo, se han visto pancreatitis asociadas tanto a la ingesta prolongada como a episodios de sobredosis Episodios de hepatotoxicidad son menos frecuentes en situaciones agudas. A partir de los 30 minutos pueden detectarse niveles en sangre aunque el pico se alcanza a las 4 horas.


El coma es proporcional a la dosis ingerida y se potencia por el alcohol Puede haber rabdomiolisis e insuficiencia renal aguda. La vida media del CBZE es de 8 a 14 horas En caso de convulsiones tratamiento con benzodiacepinas. Se distribuye por todos los tejidos y fluidos corporales Cruza la barrera placentaria.

Se cree que uno de los metabolitos de esta acetilhidracina es el responsable de la hepatotoxicidad inducida por INH. Si la ingesta ha sido hace menos de una hora, realizar lavado. National multicenter study of acute intoxication in Emergengy Departments of Spain. Eur J Emerg Med en prensa. Rev Esp Pediatr ; Effect of food on acetaminophen absorption in young and elderly subjects. J Clin Pharmacol ; Delayed peak acetaminophen APAP levels abstract.

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Role of drug metabolism.

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King’s College Criteria for Acetaminophen Toxicity – MDCalc

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Mechanism of action of N-acetylcysteine in the protection against hepatotoxicity of acetaminophen in rats in vivo. J Clin Invest ; Varying effects sulfhydryl nucleophiles on acetaminophen oxidation and sulfhydryl adduct formation. Biochem Pharmacol ; Dose-dependent pharmacokinetics of acetaminophen: Evidence for glutathione depletion in humans. Rumack BH, Matthew H. Acetaminophen poisoning and toxicity. Lesson of the week, Deaths from low-dose paracetamol poisoning.

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Shorter duration of n-acetylcysteine NAC for acute acetaminophen intoxicaicon. Compliance with PCC recommendations: Blood lactate as an early predictor of outcome in paracetamol-induced acute liver failure: Pharmacological basis of therapeutics, 6th ed.

New York, MacMillan Co. Levy G, Leonards JR.