Celastrus paniculatus is an herb used in Ayurvedic medicine with nootropic and neuroprotective effects. It contains several bioactive compounds including. PDF | Celastrus paniculatus ned in Ayurveda as ‘Tree of life’, a plant belonging to family Celastraceae was in use from time immemorial to treat brain. Celastrus paniculatus Accepted Name. Black oil plant . Staff Tree,. Black Oil Plant,. Black-oil Plant,. Oriental Bittersweet,. Celastrus. Sanskrit. अलवण Alavan.

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Celastrus paniculatus is a plant, the seeds of which are used to improve cognition.

India Biodiversity Portal

Preliminary evidence suggests it is also a potent intestinal relaxant. Our evidence-based analysis features 25 unique references to scientific papers. Each member of our research team is required to have no conflicts of interest, including celasttus supplement manufacturers, food companies, and industry funders. The team includes nutrition researchers, registered dietitians, physicians, and pharmacists.

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This page features 25 references. All factual claims are followed by specifically-applicable references.

Click here to see the full set of references for this page. Celastrus paniculatus is a woody fruit-bearing vine. The fruit of the plant contains seeds used in Ayurveda medicine. Celastrus paniculatus seeds are used to alleviate cognitive issues and promote intestinal health. The seeds can also pxniculatus made into an oil, which is sometimes used during massage.

The oil is used to alleviate skin inflammation and has a mild sedative effect. Studies done on rats suggest that Celastrus paniculatus seeds can also reduce cholesterol in unhealthy rats. Animal evidence suggests Celastrus paniculatus can protect the brain and improve cognition, but single dose supplementation is ineffective. The effect becomes stronger over two weeks of supplementation. Celastrus paniculatus seeds are a promising supplement for neurological and intestinal health, but much more research is needed before they can be specifically recommended for supplementation.


Traditional Celastrus paniculatus dosages start at 10 seeds, taken all at pqniculatus.

If no side effects occur, increase the dose to 15 and finally 20 seeds. Celastrus paniculatus of the family Celastraceae is a large woody climbing shrub with a yellowish bark which is referred to as Jyothismati in Ayurvedaand the dark brown oil extracted from the seeds pamiculatus as the medicinal component called Jyothismati Oil, [1] Celastrus Oil, [2] or Malkanguni Oil.

Traditional usage panjculatus this plant for medicinal purposes includes for the treatment of cognitive dysfunction, epilepsy, insomnia, rheumatism, gout, dyspepsia [1] as well as an abortifacient and depurative [5] while the oil has also been used as a massage oil for the medicinal treatment of arthritis and inflammatory skin conditions. The seeds are reported to be bitter in taste and hot in potency.

The sequesterpene alkaloids Celastrine and Celastrol 0. Paniculatin and paniculatadiol seed oil [5] [6]. Polyalcohol A-D [7] and the polyalcohol Dulcitol flowers [5]. Sequesterpene polyol esters such as Angulatueoid C, found in the chloroform extract and involved in intestinal relaxation [9] [10].

Oral ingestion of celastrus oil appears to be associated with less concentrations of noradrenaline in the rat brain alongside less urinary metabolites, suggesting less turnover. Oral ingestion of celastrus oil appears to be associated with less concentrations of dopamine in the rat brain alongside less urinary metabolites, suggesting less turnover.


Oral ingestion of celastrus oil appears to be associated with less concentrations of serotonin in the rat brain alongside less urinary metabolites, suggesting less turnover. Intraperitoneal injections of 0. Panicklatus, one study in a model of aluminum toxicity noted that oral ingestion of 0.

Celastrus Paniculatus Seed Extract – Neurohacker Collective

These beneficial changes were associated with increaes in fecal bile acids and sterols alongside a reduction in HMG-CoA activity. This was reversible as discontinuation of supplementation reduced necrosis within 30 days and after 45 days there are paniuclatus differences between the supplementation and control groups.

While histological examination did not show toxic effects, it did suggest a decrease in spermatogenesis and anti-fertility effects. Home Supplements Cognitive Function and Brain Health Celastrus paniculatus Celastrus paniculatus Celastrus paniculatus is a plant, the seeds of panixulatus are used to improve cognition.

This page is regularly updated, to include the most recently available clinical trial evidence. History Research analysis by Kamal Patel and verified by the Examine. Last updated on Oct 10, Free 5 day supplement course. Cite this page “Celastrus paniculatus,” Examine. Link to This Close.