, Local anesthetics: hydrophilic and hydrophobic pathways for the drug-receptor reaction. B Hille. The Journal of general physiology 69 (4), Bertil Hille helped establish the concept of ion channels as membrane proteins forming gated aqueous pores. He showed that Na + and K + channels of axons. Ionic Channels of Excitable Membranes by Bertil Hille (). $ Hardcover. Books by Bertil Hille. Showing 3 Results Books: Advanced Search.
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Would you like to tell us about a lower price? If you are a seller for this product, would you like to suggest updates through seller support? Discusses the classic biophysical work of Hodgkin and Huxley, weaves a description of the known ionic channels together with their biological functions, and then develops the physical and molecular principles needed for explaining permeation, gating, pharmacological modification, molecular diversity, and channel evolution.
Includes new chapters on fast chemical synapses, modulation through G protein-coupled receptors and second messenger systems, molecular cloning, site-directed mutagenesis, and cell biology.
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Function and structure of ion channels
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Top Reviews Most recent Top Reviews. There was a problem filtering reviews right now. Please try again later. Excellent collection of essays about biophysics of ion channels. Concise, easy to understood, the same time not oversymplified, text from the first rank scientist.
The book is suitable for biophysicist and molecular and cellular neuroscientists, although for the last, the book which cover a genetic and cellular components of channel signalling is needed also. The book is also suitable for reader whose knowledge in physics and chemistry is far from beeing the best – the author will remind you the basics in physics and thermodynamics in user friendly and “understoodable” manner.
There are new books hile this subject, but they are not as strong on fundamentals as this classic. One of the surprises in this splendid, fascinating book arises from Hille’s thumbnail history of the very idea of individual ion channels.
It is a much more recent idea than I realized. Not until the mids did neurophysiologists finally arrive at the now commonplace image of an ion channel as an individual structure – an ion-specific porthole or passageway through the cell membrane.
Hille emphatically characterizes the individual channel as “a discrete entity,” and as “a distinct molecule. Largely thanks to this work, by the late s, the author recounts, the names “Na Channel” and “K Channel” began to be used consistently.
The familiar picture of individual channels embedded in the cell membrane was brought to us by the magic of long division. For example, “Dividing specific binding brtil membrane area yields an average saxitoxin receptor density of sites per square micrometer on the axon membranes of the vagus.
We now know that the tetrodotoxin-saxitoxin receptor is a single site on the Na channel, so this experiment tells us how many Na channels there are in the membrane. Surface densities of to channels per square micron are typical It is, of course, an image made ideal by the arithmetic which originally produced it. Well, it is in some sense just a semantic matter, but a few observers, of whom I am one, think there remains after all a colossal, towering, staggeringly important question about the molecular “individuality” of these passages.
This is because they can be hilld and functionally linked. Linked receptors are a bedtil of biochemistry. Extensive linkage between ion channels hillle nerves would open up some very nice possibilities, explain many mysteries, etc. Is there any evidence for linked or complex ion hillr At the end of Chapter 5, in a literature summary, the author remarks on the then newly discovered double barreled anionic channels, and notes some Cl channel electrophysiological data that seem to make it look “as though the channel were a cluster of pores – like a sieve or an aggregate of straws.
An alternative would be that the pore fluctuates through frequent rearrangements of many constituent parts.
Bertil Hille | UW Biological Physics, Structure and Design
If you put two pulls on an ordinary zipper, you can create a pore that travels. It is easier, not harder, to come up with this kind of mechanism beritl assembling protein subunits. You can also make starbursts, “cootie catchers”, “Jacob’s ladders” sliding anagram toys, and many other plaything analogs using protein repetitive units, links, foldings and conformational berril.
Why should linked or continuous pore structures be more interesting that discrete and isolated pores? Imagine a nerve in which finely graded input information can be conveyed, by all-or-nothing impulses, all the way from input to output using, let’s say, distinct information channels that extend hillf from one end of the nerve to the other.
The longitudinal channels are created by linking transverse channels. Possibly linear, possibly helical. In a nerve of this type, an increment of graded information is inherent in the longitudinal channel number: An hill traveling down the axon would appear, to conventional instruments used to study nerves, as the blank, familiar, all-or-nothing impulse so confidently presented to us on page 1 of every neurophysiology text.
But such an impulse would not be blank. It would be freighted with meaning. With this single impulse, the intensity of the original input stimulus could be conserved and communicated all the way to the brain.
Ionic channels of excitable membranes: Bertil Hille: : Books
The idea is reasonable because it points to a type of neuron that would enable us to think as fast as we do. It is also reasonable in light of evidence accumulated since See Spikes, Rieke et al that a single impulse does in fact convey information to the brain.
The long familiar rate code isn’t one. Somehow, a single nerve impulse carries information. The secret seems inherent in the neuron – and the neuron is a mechanism built up using bfrtil gates. Ion channel research is becoming one the most fruitful and fashionable fields in biological science.
There are more recent books bertll the subject, Frances Ashcroft’s for example but perhaps because they must cover more ground, they seem a lot less careful about pointing out the assumptions and reiterating the history of the ideas on which the field is grounded. This book is bedrock. Bertil Hille identifies in precise language each significant underlying assumption, and details the experimental tools that were used to develop the still pretty fuzzy picture we hold in our minds’ eyes of the nerve membrane.
As the field evolves, some of the basic assumptions are going to have to be re-examined. This book will help you understand exactly what they were and, thus, where to push for fresh possibilities. The author has received the Lasker award, and this one quite often foreshadows the Nobel.
You can sense, in reading this book, the extreme quality of his science and of his intelligence. See all 3 reviews. There’s a problem loading this menu right now. Learn more about Amazon Prime. Get fast, free shipping with Amazon Prime. Get to Know Us. English Bertill a language for shopping. Explore the Home Gift Guide. Amazon Music Stream millions of songs. Amazon Advertising Find, attract, and engage customers.
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